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The physical architectures of information storage systems often dictate how information is encoded, databases are organized, and files are accessed. Here we show that a simple architecture comprised of a T7 promoter and a single-stranded overhang domain (ss-dsDNA), can unlock dynamic DNA-based information storage with powerful capabilities and advantages. The overhang provides a physical address for accessing specific DNA strands as well as implementing a range of in-storage file operations. It increases theoretical storage densities and capacities by expanding the encodable sequence space and simplifies the computational burden in designing sets of orthogonal file addresses. Meanwhile, the T7 promoter enables repeatable information access by transcribing information from DNA without destroying it. Furthermore, saturation mutagenesis around the T7 promoter and systematic analyses of environmental conditions reveal design criteria that can be used to optimize information access. This simple but powerful ss-dsDNA architecture lays the foundation for information storage with versatile capabilities.
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A vaccine volunteer receives an injection at the Chris Hani Baragwanath hospital in Soweto, Johannesburg Wednesday, June 24, 2020. Africa’s first participation in a COVID-19 vaccine trial has begun as volunteers received injections developed at the University of Oxford in Britain. /AP
Africa’s first participation in a COVID-19 vaccine trial started Wednesday as nervous volunteers received injections, while officials said the continent of 1.3 billion people cannot be left behind.
The large-scale trial of the vaccine developed at the University of Oxford in Britain is being conducted in South Africa, Britain and Brazil.
South Africa has nearly one-third of Africa’s confirmed cases with more than 106,000, including more than 2,100 deaths. The country late Tuesday reported its biggest one-day death toll of 111.
“I feel a little bit scared but I want to know what is going on with this vaccine so that I can tell my friends and others what is going on with the study,” one of the vaccine trial volunteers, Junior Mhlongo, said in Johannesburg.
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Bahrain, Kuwait and Norway have rolled out some of the most invasive COVID-19 contact tracing apps around the world, putting the privacy and security of hundreds of thousands of people at risk, an Amnesty International investigation reveals.
Amnesty’s Security Lab reviewed contact tracing apps from Europe, Middle East and North Africa, including a detailed technical analysis of 11 apps in Algeria, Bahrain, France, Iceland, Israel, Kuwait, Lebanon, Norway, Qatar, Tunisia and United Arab Emirates, some of which ranged from bad to dangerous for human rights. Bahrain’s ‘BeAware Bahrain’, Kuwait’s ‘Shlonik’ and Norway’s ‘Smittestopp’ apps stood out as among the most alarming mass surveillance tools assessed by Amnesty, with all three actively carrying out live or near-live tracking of users’ locations by frequently uploading GPS coordinates to a central server.
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