Notes:

Health Benefits of Niacinamide

The health benefits of Niacinamide are generally representative of those listed for Vitamin B3 – other health benefits of Niacinamide are listed in the topic for Vitamin B3.

Aging Process

Niacinamide (2,000 – 3,000 mg per day) may help to retard the Aging Process (at a cellular level) references and may function as a Life Extension agent.  references  The mechanism for this effect is as follows:

1. Niacinamide increases levels of Nicotinamide Adenine Dinucleotide (NAD).
2. NAD is a cofactor for the activity of Sir2p, an enzyme that upregulates the deacetylation (removal of Acetyl units) from Chromatin.
3. Chromatin (when deacetylated) provides a “protective cover” to Deoxyribonucleic Acid (DNA).
4. Extrachromasomal rDNA Circles (ERCs) (which stimulate a process known as Gene Silencing and therefore accelerate the Aging Process) are unable to issue “Cell strangulation and cellular death” messages to DNA that is protected by deacetylated Chromatin.

Cardiovascular System

Niacinamide may be an effective adjunct therapy for the early treatment of Stroke. 

Cells

Niacinamide may help to counteract excessive Oxidation (Free Radicals)-induced Apoptosis of normal, healthy Cells. 

Excretory System Niacinamide may retard the development of Diabetic Nephropathy. 

Eyes/Vision

Niacinamide may help to prevent Retinopathy. 

Immune System

Niacinamide may inhibit the growth of Leishmania

Niacinamide (applied topically) may help to prevent Skin Cancer caused by excessive exposure to Ultraviolet Radiation (UV-B form).  references

Metabolism

Niacinamide may exert potent Antioxidant effects in the Brain. 

Niacinamide may lower elevated Blood Sugar levels

Niacinamide may alleviate Hypoglycemia. 

Niacinamide may retard the development of Diabetic Nephropathy in Diabetes Mellitus patients. 

Niacinamide (2,000 mg per day) may help to prevent the onset of Diabetes Mellitus Type 1 (by protecting the Beta Cells of the Islets of Langerhans from destruction): 

Daily administration of Niacinamide reduced the incidence of Diabetes Mellitus Type 1 by from 20% of a test population to 7.1% of the test population.

Note that Niacinamide does not have any effect on patients with established Diabetes Mellitus Type 1 as its primary effect is to protect the Beta Cells that have largely all been destroyed once Diabetes Mellitus Type 1 becomes evident.

Niacinamide may stabilize Blood Sugar levels in Diabetes Mellitus Type 2 patients. 

Niacinamide may inhibit the ability of Alcohol (ethanol) to damage the Liver. 

Musculoskeletal System

Niacinamide (1,000 – 3,000 mg per day) may be an effective treatment for Osteoarthritis – Niacinamide therapy may improve the global impact of Osteoarthritis, may improve Joint flexibility, may reduce Inflammation and may permit Osteoarthritis patients to reduce their dosage of Anti-Inflammatory Drugs.  references

Niacinamide may be useful for the treatment of Rheumatoid Arthritis.  references

Nervous System

Niacinamide (1,000 mg per day) may reduce Aggressiveness (by stimulating the conversion of Lactic Acid to Pyruvic Acid).  references

Niacinamide may inhibit the damage to the Deoxyribonucleic Acid (DNA) content of Neurons that occurs during the progression of Alzheimer’s Disease.

Niacinamide (1,000 – 6,000 mg per day) may alleviate Anxiety (by enhancing the ability of GABA to bind to the Benzodiazepine Receptors within the Brain).

Niacinamide (1,000 – 3,000 mg per day) may help to treat Autism. 

Niacinamide may exert potent Antioxidant effects in the Brain. 

Niacinamide may help to prevent Parkinson’s Disease (by inhibiting the ability of MPTP to damage the Substantia Nigra). 

Niacinamide (500 – 800 mg per day) may reduce the symptoms of Phobias. 

Niacinamide (200 – 1,000 mg administered at bedtime) may improve the quality of Sleep (by binding to the Benzodiazepine Receptors of the Brain). 

Respiratory System –Niacinamide may alleviate Asthma (it protects against Histamine-induced bronchoconstriction). 

Skin–Niacinamide (gel containing 4% applied topically twice per day) may alleviate Acne. 

Niacinamide (cream applied topically) may lighten hyperpigmented areas of the Skin in Chloasma patients.

Niacinamide (applied topically) may alleviate Dry Skin (by increasing the production of Ceramides in the Stratum Corneum layer of the Skin). 

Niacinamide (3,000 mg per day) may alleviate Polymorphous Light Eruption.                 Niacinamide may be useful for the treatment of Psoriasis. 

Niacinamide (applied topically) may increase the production of Ceramides in the Stratum Corneum layer of the Skin.

Niacinamide (5% cream applied topically) may reduce Wrinkles. 

Niacinamide may Enhance the Function of these –Coenzymes–Supplemental Niacinamide increases the body’s production of Nicotinamide Adenine Dinucleotide (NAD):  Supplemental Niacinamide increases the body’s production of Nicotinamide Adenine Dinucleotide Phosphate (NADP). 

Hormones–Niacinamide (100 mg per night) may facilitate the production of Melatonin (this occurs from the fact that the body uses some of its Tryptophan for the production of Niacinamide – if pre-formed Niacinamide is provided, this “frees up” more Tryptophan for its other function, the production of Melatonin). 

Lipids–Niacinamide (applied topically) may increase the production of Ceramides in the Skin. 

Nucleic Compounds-Niacinamide may help to prevent damage to the body’s endogenous Deoxyribonucleic Acid (DNA). 

Quinones –Niacinamide is an essential cofactor for the endogenous production of Coenzyme Q10. 

Vitamins Niacinamide may increase Brain Choline levels

Niacinamide can be converted within the body to Nicotinic Acid (however Nicotinic Acid cannot be reconverted back to Niacinamide). 

Niacinamide may Counteract these Potentially Toxic Substances –Aldehydes–Niacinamide may lower Acetaldehyde levels by up to 50%.

Electromagnetic Radiation –Niacinamide (applied topically) may help to prevent Skin Cancer caused by excessive exposure to the UV-B form of Ultraviolet Radiation

Lipids–Niacinamide may counteract the toxic effects associated with Lipopolysaccharides. 

Neurotoxins–Niacinamide may inhibit the ability of MPTP to damage the Substantia Nigra and subsequently cause Parkinson’s Disease. 

Recreational Drugs—Niacinamide may inhibit the ability of Alcohol (ethanol) to damage the Liver.  Niacinamide may reduce the craving for Alcohol in persons afflicted with Alcoholism:  references

Niacinamide may lower Acetaldehyde levels by up to 50%. 

Approximately 66% of the body’s Niacinamide content is derived from the metabolism of Tryptophan.—Niacinamide is absorbed only via the Small Intestines. -After its oral absorption, Niacinamide is present in the Blood plasma and is converted to its coenzyme form in Blood Cells, the Kidneys, the Brain and the Liver.

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